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Shocking Causes of High SGPT: Are You at Risk?

Dr. Pankaj Mandale 2863 Views
Published: 22 Oct 2024
Updated: 28 Oct 2024
Causes of High SGPT

Have you ever been told that your SGPT levels are high? This might seem like just another number from a blood test, but in reality, it’s a key indicator of your liver’s health. When SGPT (also known as ALT) is elevated, it can signal potential liver damage, but don’t panic just yet. Elevated SGPT levels can be caused by various factors, some serious and others less so. In this article, we’ll unravel the causes of high SGPT and how to keep your liver healthy. Let’s start by understanding what SGPT is and why it matters for your liver health.

What is SGPT and Why is It Important?

SGPT (Serum Glutamate Pyruvate Transaminase) is an enzyme primarily found in the liver. It plays a vital role in converting proteins into energy for the liver cells. When liver cells are damaged, SGPT is released into the bloodstream, which is why higher levels of this enzyme can indicate liver injury. 

ALT (alanine aminotransferase), another name for SGPT, is used interchangeably. Testing for SGPT gives doctors an idea of your liver function and whether your liver is suffering from any disease or damage. 

Understanding the SGPT Normal Range

The SGPT normal range varies slightly depending on the laboratory but generally falls between 7 to 56 units per liter (U/L) of blood. If your test results show levels within this range, your liver is likely functioning normally. However, if the results are above this range, it could indicate liver issues. 

In addition to SGPT, many doctors check SGOT (aspartate aminotransferase). The SGPT and SGOT normal range together help assess liver health. 

Common Causes of High SGPT

When it comes to elevated SGPT levels, it’s essential to know the root causes. Some of the most common causes include: 

  1. Non-Alcoholic Fatty Liver Disease (NAFLD) 
  2. Alcoholic Liver Disease 
  3. Viral Hepatitis (Hepatitis B, C, etc.) 
  4. Drug-induced liver injury 
  5. Autoimmune Hepatitis 
  6. Hemochromatosis (excess iron) 
  7. Wilson's Disease (copper accumulation) 
  8. Heart Attacks 

These conditions range from mild to severe, but all can potentially harm your liver.

Non-Alcoholic Fatty Liver Disease (NAFLD) 

One of the most prevalent causes of high SGPT is NAFLD, a condition where fat builds up in the liver, unrelated to alcohol consumption. The exact cause of NAFLD isn’t clear, but it’s commonly linked to obesity, diabetes, and high cholesterol. Left untreated, it can lead to liver inflammation, scarring, and eventually liver failure. 

Alcoholic Liver Disease

As the name suggests, alcoholic liver disease is caused by excessive alcohol consumption. Alcohol damages liver cells, leading to inflammation and increased SGPT levels. This can progress to cirrhosis (liver scarring), which is irreversible and potentially fatal if left untreated. 

Viral Hepatitis and Its Impact on SGPT

Hepatitis B and C are viral infections that cause inflammation of the liver. These infections can lead to chronic liver disease, liver cancer, and elevated SGPT levels. Early detection through liver function tests, including the SGPT test, is crucial for proper management. 

Other Medical Conditions Affecting SGPT

Besides liver diseases, several other medical conditions can cause elevated SGPT, including: 

  • Heart attack: When a heart attack occurs, enzymes like SGPT can increase as heart cells are damaged. 
  • Muscle diseases: Some muscle disorders can lead to increased SGPT. 
  • Hypothyroidism: An underactive thyroid can also affect liver enzyme levels. 

Symptoms of High SGPT

High SGPT levels often don’t cause symptoms on their own, but the underlying conditions might. Some signs that could indicate liver damage include: 

  • Fatigue 
  • Jaundice (yellowing of the skin and eyes) 
  • Abdominal pain or swelling 
  • Dark urine 
  • Nausea or vomiting 

If you experience any of these symptoms, it’s important to consult a healthcare professional.  

How to Lower SGPT Levels

Maintaining healthy liver function is key to lowering your SGPT levels. Here are some steps you can take: 

  • Eat a balanced diet: Include more vegetables, fruits, and lean proteins. 
  • Exercise regularly: Physical activity can help reduce fat in your liver. 
  • Limit alcohol consumption: Alcohol can significantly harm your liver. 
  • Avoid certain medications: Some over-the-counter drugs and supplements can increase liver enzyme levels. Always consult your doctor. 

Risk Factors for High SGPT

Several risk factors increase the likelihood of elevated SGPT, such as: 

  • Obesity 
  • Diabetes 
  • Excessive alcohol consumption 
  • High cholesterol 
  • Viral hepatitis 

Understanding these risk factors can help you take proactive steps to protect your liver. 

Prevention of Liver Damage

Preventing liver damage is easier than treating it. To keep your liver healthy, follow these tips: 

  • Get vaccinated for hepatitis: Hepatitis A and B vaccines are available and can prevent liver infections. 
  • Limit alcohol: Stick to recommended guidelines or avoid alcohol entirely. 
  • Maintain a healthy weight: Obesity is a leading cause of liver disease, so weight management is crucial. 

How to Get an SGPT Test Done?

You can easily get an SGPT test done at any diagnostic lab or hospital. There are also online SGPT tests where you can book your test, get a home sample collection, and receive results digitally. It’s important to get tested if you suspect liver issues or as part of regular health checkups.

Conclusion

High SGPT levels can be a warning sign of liver damage, but with early detection and proper management, many liver conditions can be treated or even reversed. Whether it’s due to NAFLD, viral hepatitis, or other causes, paying attention to your liver health is crucial. If you’ve noticed symptoms or have risk factors, consider getting an SGPT test and make the necessary lifestyle changes to protect your liver.

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Specimen : WB EDTA

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Component : CBC, ESR, BSF/BSR, HbA1c, Lipid Profile, Liver Function Test (Bilirubin Total, Direct & Indirect, SGOT, SGPT, AST/ALT Ratio, ALP, Total Protein, Albumin, Globulin, A/G Ratio), Kidney Function Test (Urea, BUN, Creatinine, Bun/Creatinine Ratio, Calcium, Uric Acid, Electrolytes (Na/K/Cl), Iron, UIBC, TIBC, % Saturation, T3, T4, TSH, Vit B12, Vit D, HBsAg (Rapid), Urine R/M), GGT & Phosphorus

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Specimen : Serum

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